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WCDG meets monthly September to May on the 3rd Wednesday of the month. Meetings are public and include a light dinner & social hour followed by a speaker. To join our mailing list, email washchrom@gmail.com. Follow us on Twitter
@WashChrom & LinkedIn.


We have a NEW website. Please visit www.washchrom.com for updates. We will close this squarespace website soon.
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Upcoming Events

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7th Annual Poster Session & Vendor Exhibition

September 20, 2017  6:00PM-8:00PM
Bethesda North Marriott Hotel & Conference Center
5701 Marinelli Road, North Bethesda, MD 20852
download flyer      registration page


October Meeting
Wednesday, October 18, 2017

Marvel Hall, ACS Headquarters, 1155 16th St, NW, Washington, DC (Directions)
6:00PM dinner & social
7:00PM presentation

Speaker:
Dr. John Hanover, National Institute of Diabetes and Digestive and Kidney Diseases
Title: A Little Sugar goes a Long Way:  O-GlcNAc in human disease

O-GlcNAc is a single monosaccharide modification of nuclear and cytoplasmic proteins. O-GlcNAcylation is driven by the nutrient-sensing hexosamine biosynthetic pathway and may rival protein phosphorylation in its abundant and impact on cellular signaling.  Emerging evidence suggests that this modification may also have far-reaching consequences for chronic human diseases including cancer, diabetes and neurodegeneration. Findings in C. elegans, Drosophila and mouse model systems have demonstrated that the dynamic turnover of O-GlcNAc is critical for maintaining levels of key transcriptional regulators responsible for neurodevelopment fate decisions.  In addition, pathways of autophagy and proteasomal degradation depend upon a transcriptional network dependent upon O-GlcNAc cycling.  Like the quality control system in the endoplasmic reticulum which uses a “mannose-timer” to monitor protein folding, we propose that cytoplasmic proteostasis uses an “O-GlcNAc timer” that helps to regulate the lifetime and fate of cytosolic proteins.  Worm, fly and mouse models harboring O-GlcNAc transferase and O-GlcNAcase knockout alleles have helped define the role O-GlcNAc plays in development and age-associated neurodegenerative disease. We anticipate that brain-selective knockout mouse models will be an important tool for understanding the role of O-GlcNAc in the physiology of the brain and its susceptibility to neurodegenerative injury. Blocking O-GlcNAc cycling is detrimental to mammalian brain development and interferes with neurogenesis, neural migration, and proteostasis. O-GlcNAc-dependent developmental alterations impact metabolism and growth of the developing mouse embryo and persist into adulthood. Thus, O-GlcNAcase is both a promising diagnostic and therapeutic target for human neurodegenerative disease. O-GlcNAc may also trigger a global reprograming of metabolism in cancer and metabolic disease.



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Past Events

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2016 Open House & Poster Session

September 22, 2016 at Bethesda North Marriott Conference Center


Congratulations to Sam Choi, our 2016 winner of the Georges Guiochon travel award for best student poster at the WCDG Open House & Poster Session on September 21!
Sam Choi from George Washington University won the award for his outstanding poster on "CE-nanoESI-MS for Untargeted Proteomic Characterization of Single Embryonic Cells and Small Neuron Populations". He will receive complementary travel to a separations-related conference of his choice. Congratulations, Sam!

We also want to acknowledge our Honorable Mentions, Erika Portero and Rosemary Onjiko from George Washington University, and thank all of our poster presenters, vendors, and attendees for making this year's event a success! Download 2016 Program


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3rd Annual Chromatography & Separations Community Mixer

March 10, 2015 at Generations Hall New Orleans


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2014 Open House & Poster Session

Rockville, MD
Program


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2014 Chromatography Community Mixer

Chicago, IL